CHRONIC SENSORY CONTACT WITH SUBORDINATED CONSPECIFICS PROMOTES SPLENIC GLUCOCORTICOID RESISTANCE IN EXPERIMENTALLY WOUNDED C57BL/6N MALE MICE

Chronic sensory contact with subordinated conspecifics promotes splenic glucocorticoid resistance in experimentally wounded C57BL/6N male mice

Abstract Chronic psychosocial stress induced by the chronic subordinate colony housing (CSC, 19 Days) paradigm promotes functional splenic in vitro glucocorticoid (GC) resistance, but only if associated with significant bite wounding or prior abdominal transmitter implantation.Moreover, sensory contact to social defeat of conspecifics represents a

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Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability

Synapses are particularly susceptible to the effects of advancing age, and mitochondria have long been implicated as organelles contributing to this compartmental vulnerability.Despite this, the mitochondrial molecular cascades promoting age-dependent telemarkskongen flue synaptic demise remain to be elucidated.Here, we sought to examine how the sy

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Non-surgical therapy for the treatment of chronic low back pain in patients with Modic changes: A systematic review of the literature

Background: In absence of uniform therapeutic recommendations, knowledge of the available treatment options for Modic changes (MCs) patients and their safety and effectiveness would be crucial and significant for clinicians and such patients.Objectives: The aim of this study was to provide a systematic review of available studies on non-surgical tr

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Maternal milk and fecal microbes guide the spatiotemporal development of mucosa-associated microbiota and barrier function in the porcine neonatal gut

Abstract Background The early-life microbiota exerts a profound and lifelong impact on host health.Longitudinal studies in humans have been informative but are mostly based on the analysis cubs foam finger of fecal samples and cannot shed direct light on the early development of mucosa-associated intestinal microbiota and its impact on GI function.

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